winterblanco
19.10.2019 •
Biology
How are sterol regulatory element binding proteins (srebps) able to activate transcription of multiple genes in the cholesterol biosynthesis and uptake pathway in response to stimuli such as low cholesterol levels or insulin? o choose one: a. srebps enhance transcription of all genes in cells in response to stimuli b. in response to a stimuli, multiple srebps are activated, each with a separate target. c. srebp target genes all contain a similar dna sequence in their promoter d. srebp activation reduces cholesterol content, which in turn activates transcription of cholesterol biosynthesis genes.
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Ответ:
The correct answer is option C. "SREBP target genes all contain a similar DNA sequence in their promoter".
Explanation:
Sterol regulatory element binding proteins (SREBPs) are lipid synthetic transcription factors that work in different pathways but particularly for cholesterol and fatty acid synthesis. SREBPs have this versatility because they target genes all contain a similar DNA sequence in their promoter. For instance the protein SREBP-1, have been identified that binds to most gene promoters that participate in sterol biosynthesis.
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