How does the shape of a protein relate to its function? Refer to specific details about this case and sickle cell anemia

Renaissance women had less freedom than men ↔ Low class women were expected to be housewives and take care of everything to do with the house. Working-class women were expected to help their husbands run their business. They were denied all political rights and considered legally subject to their husbands.

The plague nearly destroyed Italy's economy ↔ It became harder and harder to find people to plow fields, harvest crops, and produce other goods because of the amount of people dying. Peasants also began to demand higher wages. Lasted from 1629 to 1631 and killed more than 45,000 people in Venice alone. It wiped out over half the population.