Measure that determines the state of a substance

That would be temperature.
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Answer;

Prokaryotes only have one origin of replication to initiate replication.

Explanation;DNA replication is a process that takes place in living organisms which involves copying DNA strands to form identical new strands.The process is a semi-conservative process meaning that the newly synthesized strands each contains one strand from the original DNA strand and one new strand. This process is catalyzed by enzyme DNA polymerase.The process of DNA replication is initiated at a point called origin of replication by enzyme DNA polymerase. Prokaryotes have only one origin of replication while eukaryotes have multiple origins of replication.