samehajamal1234567
05.05.2020 •
Biology
The genetic code is thought to have evolved to maximize genetic stability by minimizing the effect on protein function of most substitution mutations (single-base changes). We will use the six arginine codons to test this idea. Consider all of the substitutions that could affect all of the six arginine codons.Part A How many total mutations are possible?Part B How many of these mutations are "silent," in the sense that the mutant codon is changed to another Arg codonPart C How many of these mutations are conservative, in the sense that an Arg codon is changed to a functionally similar Lys codon?
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Ответ:
The six codons for arginine are the following:
GCA, GCG, GCT, GCC, TCT, TCC
A) Considering the individual bases in each codon, three mutations are possible at each base position. Hence, 3 × 3 × 6 = 54 mutations are possible.
B) Considering the mutations at the 3rd base: 3 × 4 + 1 × 2 = 14 of these mutations are silent mutations.
C) Lysine codons are the following:
TTT, TTC
There are two possible mutations that can give a lys codon.
Hope that answers the question, have a great day!
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