You visit a huge city with millions of people. If you were to start sampling the cystic fibrosis allele from one generation to the next, what should happen to its frequency over the next few generations, and why?

The frequency would be stable.

Explanation:

Based on the most common symptoms of cystic fibrosis, the disease only appears on adults and elderly. This feature means that the frequency of the disease would not drop or raise because they would still reproduce and pass the allele from generation to the next, maintaining the frequency stable.