Can an enzyme be reused with a new substrate

At the end of the reaction, the product/s are formed, the enzyme remains unchanged, can bind another substrate and can be reused many times.

Answer is: The ions in the solute separate from each other.

For example, dissociation of potassium iodide in water:  

KI(aq) → K⁺(aq) + I⁻(aq).

Solvation is the interaction of solvent (water) with molecules or ions (in this example K⁺ and I⁻) in a solute.  

Anion I⁻ has negative charge, so positive end (hydrogen atoms) of a water molecul attracts them.