Fastest answer = brainlist, answer both.

Issue: Covered in a standard yearly message conveyed to Congress by President James Monroe in December 1823, the tenet cautions European countries that the US would not endure further colonization or manikin rulers.

What It Started: Monroe Doctrine alerts European nations that the US would not persevere through additional colonization or puppet rulers. It was unsuccessful

Issue: In 1820, in the midst of developing sectional strains over the issue of bondage, the U.S. Congress passed a law that conceded Missouri to the Association as a slave state and Maine as a free state, while restricting servitude from the leftover Louisiana Buy lands found north of the 36º 30' equal

What it Started: The Missouri Bargain was ineffectual in managing the issue of bondage since it expanded sectionalism among Northern and Southern states. Rather than addressing this issue of bondage in new domains Congress just expanded the pressure among North and South

The search for sea routes to Asia was already going on in advance of the fall of Constantinople. The Atlantic-facing powers of Spain and Portugal were determined to cut the middlemen out of their trade with the Far East and become new masters of the importation of silk and spices. While complications in east-west trade were posed by the fall of Constantinople, that event did not choke off that trade. Europe continued to import goods from the east at slightly higher prices and with temporary interruptions through Ottoman (rather than Byzantine) Constantinople and without interruption through Mamluk Egypt.