Federalists in the Northeastern states became worried about the acquisition of the Louisiana Territory and considered the possibility of seceding because

There were more than two dozen Native American groups living in the southeast region, loosely defined as spreading from North Carolina to the Gulf of Mexico. These groups included the Chickasaw (CHIK-uh-saw), Choctaw (CHAWK-taw), Creek (CREEK), Cherokee (CHAIR-oh-kee), and Seminole (SEH-min-ohl)