The figure in the center of the painting represents... Growth in technology and industry in the United States

American belief in development and expansion of the West

the souls of pioneers who died on the Oregon Trail

the Great Spirit protecting Native American settlers ​

Explanation is in the file

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Explanation:

the disease had a terrible impact. Generally speaking, a quarter of the population was wiped out, but in local settlements often half of the population was exterminated. The direct impacts on economy and society were basically a reduction in production and in consumption.