The region from the Tigris and Euphrates Rivers and along the Mediterranean Sea was known as O the Red Sea
O the Knesset
O the Nile River
O Macedonia
O the Fertile Crescent
O Canaan

I believe this region is the Fertile Crescent

Agriculture is thought to have developed independently throughout the world, so there is not necessarily one particular group of people that could be considered to be the first. However, of the available options the most likley to be correct would be a) Nomads in Central Asia. The 'fertile crescent' in the East is often referred to in this respect, as being the first place agriculture was properly developed.