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Calliedevore
01.06.2021 •
Mathematics
In the Salk vaccine field trial, 400,000 children were part of a randomized controlled double-blind experiment. Just about half of them were assigned at random to the vaccine group, and the other half to the placebo.16 In the vaccine group, there were 57 cases of polio, compared to 142 in the placebo group. Is this difference due to chance? If not, what explains it?
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Ответ:
Step-by-step explanation:
From the given information:
The number of children that were randomly allocated to each vaccination group; n₁ = 200,000
No of polio cases X₁ = 57
Now, in the vaccine group:
the proportion of polio cases is:
= 0.000285
The number of children that were randomly allocated to the placebo group, n₂ = 200,000
No of polio cases X₂ = 142
In the placebo group
the proportion of polio cases is:
Null and alternative hypothesis is computed as follows:
H₀: There is no difference in the proportions of polio cases between both groups.
H₁: There is a difference in the proportions of polio cases between both groups.
Let assume that the level of significance ∝ = 0.05
The test statistic can be computed as:
Z = - 6.03
P-value = 2P(Z < -6.03)
From the Z - tables
P-value = 2 × 0.0000
= 0.000
We reject the H₀ provided that P-value is very less.
Therefore, we may conclude that there is a difference in the proportions of polio cases between the vaccine group and placebo group not due to chance.
Ответ: