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meandmycousinmagic
17.10.2019 •
Biology
Does mitochondrial protease prevent demyelination and greying?
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Ответ:
The mutation that involves the change in the sequence of DNA bases is reflected both in the transcription of mRNA and in translation, giving rise to an alteration in the protein, which may not function and whose impact on the organism is a morphological or functional alteration.
Explanation:
According to this scenario, the DNA has experienced a mutation by changing the sequence by one of its bases, Cytosine by Thymine, producing in the mRNA a termination codon that interrupts the normal synthesis of the protein, preventing that protein from fulfilling its function. This particular mutation is called Nonsense mutation.
For normal DNA
DNA TAC CTC ACC GAG CGT
mRNA AUG GAG UGG CUC GCA
Protein Met - Glu - Trp - Leu - Ala
For the mutated DNA
DNA TAC CTC ACT GAG CGT
mRNA AUG GAG UGA CUC GCA
Protein Met - Glu - STOP - Leu - Ala
The change of a cytosine by Thymine in the mutated DNA produces that the third codon of the mRNA is altered, encoding a UGA termination codon, which prematurely stops the protein synthesis and originates an incomplete protein, probably not functional, whose impact in the organism is a morphological or functional alteration.