Even though cancer genomes are overall hypomethylated, explain why some genes are hypermethylated in cancer cells. Drag the terms on the left to the appropriate blanks on the right to complete the sentences. A. DNA repair genes B. OncogenesC. Cell Cycle stop genesD. Are not expressedE. HypomethylationF. HypermethylationG. Are expressed H. protein-coding genespromoters will lead to reduced expression of the correspondent genes. Some genes such asandneed to be expressed. When they, this can lead to cancer.

Hypermethylation of___ promoters will lead to reduced expression of the correspondent genes. Some genes such as Cell Cycle stop genes _and__DNA repair genes_need to be expressed. When they__are not expressed_, this can lead to cancer.

Explanation:

Oncogenes are genes that may trigger cancer, where they are generally overexpressed (i.e., expressed at high levels). Although there are well-documented exceptions to this rule, DNA methylation generally represses gene expression by preventing the binding of transcription factors to promoters. It is known that the hypermethylation of tumor suppressor genes including, for example, cell cycle stop genes and DNA repair genes, may lead to cancer. Similarly, hypomethylation of oncogenes such as, for example, Cyclin D1 (a cyclin-dependent kinase involved in cell cycle progression), may also contribute to carcinogenesis.

Explanation:

"As a starter we present our goat cheese served with natural fermented bread and confit tomato sauce. The cheese used in our restaurant is manufactured by small regional producers, as well as the wheat used in bread, and tomatoes, which are planted and harvested organically, free of pesticides and allergens."

The benefits of using a local food supply chain instead of a local one in a restaurant is to value local micro producers, and to collaborate with the development of the local economy.

For the restaurant, this strategy will help it to position itself as a company that uses artisanal ingredients in its dishes, which is an important differentiation from competitors, and will also position it as a company that promotes local development, which it increases its value to stakeholders and its reliability.