Instead of manipulating organisms, selective breeding genetic engineeringhybridization manipulates their genes.

Option B , Genetic Engineering

Explanation:

Genetic Engineering is a process in which genes are modified or manipulated directly through applications of biotechnology. Basically the DNA of one organism is copied or isolated and the gene of other organism is inserted into the isolated gene through the recombination DNA technology with in any bacteria for artificial synthesis of DNA.

While both hybridization and selective breeding are  form of organisms manipulation.

Hence, option B is correct