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Traditional Pathology: Traditional pathology involves removing cell culture models from well plates and processing them. Despite the fact that this method may obtain pathological information from tissues, the scale of these models makes the process extremely low-throughput, time-consuming, and costly.

Dissolution Based Assays: Many researchers are currently using dissolution based assays where cell culture models are homogenized and analyzed using a fluorescence probe such as Promega’s CellTiter-Glo Luminescent kit. While these assays are high-throughput, they do not capture the 3D data held within these models which makes them intrinsically more valuable than traditional 2D cell culture models.