![mathman783](/avatars/32097.jpg)
mathman783
26.09.2019 •
Biology
Tropical rainsforest cover a small part of the planet
Solved
Show answers
More tips
- H Health and Medicine How to Help Men Gain Weight?...
- A Auto and Moto Discovering the Leader: What is the Most Expensive Car in the World?...
- H Health and Medicine Hangover: How to Get Rid of It Quickly?...
- S Style and Beauty How to Choose the Right Fur Coat and Avoid Regrets?...
- C Computers and Internet How to Create a Folder on Your iPhone?...
- G Goods and services How to sew a ribbon: Tips for beginners...
- F Food and Cooking How to Make Mayonnaise at Home? Secrets of Homemade Mayonnaise...
- C Computers and Internet Which Phone is Best for Internet Surfing?...
- F Food and Cooking Everything You Need to Know About Pasta...
- C Computers and Internet How to Choose a Monitor?...
Answers on questions: Biology
- B Biology Potential benefits of pH 8.8 alkaline drinking water as an adjunct in the treatment of reflux disease: 1. Who are the authors of this article? (0.5pt) st-Lab Search...
- B Biology What is not part of the hepatic portal system?...
- B Biology Will give brainliest!! thank you...
- B Biology Tous 13v NEAL Preces 13 Select the correct answer from each drop-down menu. ✓ can be Mutations are random changes to the structure of a gene. The likelihood of a mutation...
- B Biology 5. Which two systems below are most important when a person throws a dart? PLEASE HELPP!! A skeletal and circulatory systems C integumentary and skeletal systems B respiratory...
- B Biology Gas exchange, transport, abortion, protection Help meee please...
- B Biology BIOLOGY DNA SECTION 1 1. Why does DNA replicate? 2. Is DNA replication describe as conservative or semi-conservative? Why? 3. What 2 enzymes are used during DNA replication?...
- B Biology Nursing care of a patient with acquired immune deficiency syndrome (AIDS) includes monitoring of T-lymphocyte counts. Explain why....
- B Biology What is the primary energy molecule in cells?...
- B Biology Someone help, i’ve been stuck on this for awhile :/...
Ответ:
Ответ:
One of the common genetic disorders is sickle cell anemia, in which 2 recessive alleles must meet to allow for destruction and alteration in the morphology of red blood cells. This usually leads to loss of proper binding of oxygen to hemoglobin and curved, sickle-shaped erythrocytes. The mutation causing this disease occurs in the 6th codon of the HBB gene encoding the hemoglobin subunit β (β-globin), a protein, serving as an integral part of the adult hemoglobin A (HbA), which is a heterotetramer of 2 α chains and 2 β chains that is responsible for binding to the oxygen in the blood. This mutation changes a charged glutamic acid to a hydrophobic valine residue and disrupts the tertiary structure and stability of the hemoglobin molecule. Since in the field of protein intrinsic disorder, charged and polar residues are typically considered as disorder promoting, in opposite to the order-promoting non-polar hydrophobic residues, in this study we attempted to answer a question if intrinsic disorder might have a role in the pathogenesis of sickle cell anemia. To this end, several disorder predictors were utilized to evaluate the presence of intrinsically disordered regions in all subunits of human hemoglobin: α, β, δ, ε, ζ, γ1, and γ2. Then, structural analysis was completed by using the SWISS-MODEL Repository to visualize the outputs of the disorder predictors. Finally, Uniprot STRING and D2P2 were used to determine biochemical interactome and protein partners for each hemoglobin subunit along with analyzing their posttranslational modifications. All these properties were used to determine any differences between the 6 different types of subunits of hemoglobin and to correlate the mutation leading to sickle cell anemia with intrinsic disorder propensity.
Explanation: