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Scleroderma

Explanation:

Scleroderma which is also called systemic sclerosis is a rare group of disorders that affects more women than men, in which the skin and connective tissues become hardened and tightened over time.

Scleroderma is said to be caused by the abnormal production and accumulation of collagen in the tissues of the body, of which he immune system plays a major role. This can be triggered by factors such as immune system problem, genetic and environmental factors. Symptoms might include, muscle weakness,painful and swollen joints, sores on fingertips, cold fingers, hardened or thickened skin etc .