Babygirljay1540
21.07.2019 •
Biology
What happens every time our cells divide
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Ответ:
Ответ:
Answer & explanation:
Succinylcholine is a depolarizing neuromuscular blocker, these substances bind to the nicotinic receptor and act as acetylcholine, depolarizing the neuromuscular junction.
However, unlike acetylcholine, which is instantly destroyed by acetylcholinesterase, depolarizing blockers persist in high concentration in the synaptic cleft, remaining bound to the receptor for a relatively longer time and causing constant receptor stimulation.
This mechanism causes the opening in sodium (Na⁺) channels, producing transient fasciculations and flaccid paralysis. After that, the membrane repolarizes, but the receptor is resuscitated by the effect of acetylcholine.
The difference in mechanisms is precisely due to the fact that acetylcholine is rapidly degraded (as a result of acetylcholinesterase), while succinylcholine persists for a relatively longer time to the receptor due to its high concentration in synaptic clefts.