What was a major effect of the growth of the ottoman empire?

The effect of the growth of ottoman empire is depopulation from the plague and it contribute to the weakening of byzantine empire and depopulation of Constantinople.

Explanation:

After 1100 years, the "capture of Constantinople" put an end to the byzantine empire.The effect on this christian Europe was expensive. The unexpected  effect was many scholars run away from new empire and moved to 'Italy' where they increases the trade with east. The ottoman empire was much important for two factors - it was more 'powerful' and it was the Muslims who are consider as weak of byzantine empire.

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