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sciencefanfae7248
27.02.2020 •
Chemistry
Arrange the events for the hydrolysis of amide bonds by chymotrypsin in their correct order. 1) attack by ser 195 to give a tetrahedral intermediate 2) enzyme returns to initial state 3) protonation by his 57 and then cleavage of the c-n bond release the c-terminal fragment 4) protonation by his 57 and then cleavage of the c-o bond release the n-terminal fragment 5) attack by water, leading to formation of a tetrahedral intermediate 6) binding of substrate to properly position the scissile bond for cleavage
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Ответ:
The correct order is : 6,1,3,5,4,2.
Explanation:
Events of Hydrolysis of amide bonds by chymotrypsin is as follows:
Firstly, 6, Binding of Substrate to properly position the scissile bond for cleavage.
Then, 1, attack by ser 195 to give a tetrahedral intermediate
3, protonation by his 57 and then cleavage of the c-n bond releases the c-terminal fragment
5, attack by water, leading to formation of a tetrahedral intermediate
4, protonation by his 57 and then cleavage of the c-o bond releases the n-terminal fragment
2, enzyme returns to initial state
Ответ:
The correct answer is C
Explanation: I took the test