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denym58
denym58
14.07.2020 • 
Chemistry

Aspirin synthesis involves the addition of an acetyl group to salicylic acid in a condensation reaction with an alcohol. The acetyl group could be added with a carboxylic acid but the preferred procedure is to use the acid anhydride.Why is preferable to use an acid anhydride for ester formation with an alcohol rather than a carboxylic acid?Select one:1. Acid anhydrides are less stable than esters so the equilibrium favors the ester product.2. Carboxylic acids change the pH of the solution too much for the reaction to proceed.3. Carboxylic acids react with water in an undesired side reaction.4. Acid anhydrides are generally easier and safer to handle than carboxylic acids.

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