How many principal routes did the cherokee take to indian territory?

The correct answer is the East of the Mississippi River.

Explanation:

This route is known as the Trai of Tears, when the Cherokees were thrown out of their land.

The answer is:

The major industrial cities became overcrowded as workers from rural areas moved there.

and

Because of the steady increase in food production, the population nearly doubled between 1800 and 1850.