The___was the first piece of legislation that defined what a prescription is and who could authorize the use of prescription drugs.

Explanation:

The schedules are designated schedule I, schedule II, schedule III, schedule IV, and schedule V. Many drugs require a prescription, even though they are not a controlled substance. The safety and the effectiveness of prescription drugs in the US are regulated by the 1987 Prescription Drug Marketing Act (PDMA).

Large, wealthy, and sophisticated

Explanation:

Both of these empires had large populations, so the first choice would not be correct. This is the same reason why the third choice is incorrect. The fourth choice is incorrect because the Aztecs and Incas were advanced, had gold, and the buildings were impressive for their time.