What are some disadvantages of being a noble in the Middle Ages?

More responsibility, had to fight in wars, make hard decisions

Disadvantages:
Less money, bad foods, had to do hard labor, long working hours, didn't get paid much/at all, serfs could not leave without permission

Nullification is a legal theory that a state has the right to invalidate, any federal law which that it deems unconstitutional with respect to the United States Constitution. An example is when South Carolina adopted the ordinance to nullify the tariff acts and label them unconstitutional. During the Civil War  several states threatened or attempted nullification of various federal laws