You can tell his painting is from the Renaissance because its shows two

i didn't understand

 America must extend commercial relations with Europe while insuring that the US has as little to do with European politics as possible. This is because if America gets too involved with European politics, then the US will lose more money in European wars that do not truly affect them.
Significance: This was the first principle of American foreign policy. Peace, commerce, and honest friendship with all nations, entangling alliances with none.