Describe one hypothetical situation/behavior that illustrates the “use it” portion of the use it or lose it principle. Explain why more bone is present under these circumstances.

An inhibitor that can be used to block the release of calcium from the endoplasmic reticulum is PHOSPHOLIPASE C.

Explanation:

Phospholipase C is an enzyme that cleaves phopholipids, it does this through addition of water molecules. The enzyme is membrane associated, this means that it always act at the surface of cells. Phospholipase C can also acts as an inhibitor, for instance, it can prevents the release of calcium from the endoplasmic reticulum. Calcium serves as a second messenger in the phospholipase C signal transduction pathway and its release can be inhibited or activated by the enzyme.