Li-Fraumeni syndrome (LFS1) is a rare hereditary disorder that leads to a predisposition to cancer. This hereditary disorder is linked to mutations in the tumor suppressor gene encoding the transcription factor p53. p53 acts at the G1 checkpoint. If damaged DNA is detected, p53 halts the cell cycle. As p53 levels rise, the production of p21 is triggered. p21 enforces the halt in the cell cycle. A variant of Li-Fraumeni, called LFS2, is thought to occur due to a mutation of the CHK2 gene, which is also a tumor suppressor gene. CHK2 regulates the action of p53. Which of the following cascades is most likely to occur in a normal cell that does not contain the LFS mutation?
Solved
Show answers
More tips
- F Family and Home How to Choose a Name for Your Baby?...
- B Business and Finance How to Open an Online Store? A Detailed Guide for Beginners...
- W Work and Career How to Write a Resume That Catches the Employer s Attention?...
- C Computers and Internet Е-head: How it Simplifies Life for Users?...
- F Family and Home How to Choose the Best Diapers for Your Baby?...
- F Family and Home Parquet or laminate, which is better?...
- L Leisure and Entertainment How to Properly Wind Fishing Line onto a Reel?...
- L Leisure and Entertainment How to Make a Paper Boat in Simple Steps...
- T Travel and tourism Maldives Adventures: What is the Best Season to Visit the Luxurious Beaches?...
- H Health and Medicine Kinesiology: What is it and How Does it Work?...
Answers on questions: Biology
- B Biology How is it posibal to have ionic and covalent bonds...
- M Mathematics What are the two local minimums on the graph of function f? I know the max is 0,4 please help...
- M Mathematics A space ship travels at 9^15 miles per hour and traveled continuously for 9^18 hours. Enter the answer, in the form of x, that represents how many miles the space ship traveled....
- H Health Pbgjyeakrr j.o.i.n..t.o..s.h.o.w..b.o.o .b.s...
Ответ:
CHK2, p53, p21, cell cycle progression.
Explanation:
In a normal cell with no LFS mutation, during the G1 stage of cell cycle progression, the CHK2 activates if there is damage in the DNA. CHK2 activates p53, which is a tumor suppressor protein that will hold the cell cycle in G1/S until the DNA is repaired. The p53 protein activates p21, a protein that binds to CDK2 and stops the cell cycle. The cell cycle will continue once the damage is repaired.
Ответ: