huwoman
huwoman
18.12.2019 • 
Biology

Protein degradation. a protein known as a mitotic cyclin is an example of a protein that is selectively degraded at aparticular point in the cell cycle. namely, the onset of the portion of the cell cycle known as anaphase. suppose that youuse recombinant dna techniques to create a mutant form of mitotic cyclin that is not degraded at the onset of anaphase.(a) sequence analysis of the mutant mitotic cyclin shows that it is missing a stretch of nine amino acids near one end of themolecule. based on this information, provide at least three possible explanations of why this form of mitotic cyclin is notdegraded at the onset of anaphase.(b) what kinds of experiments could you carry out to distinguish among these various possible explanations? (: 1 suppose that you discover cells containing a mutation in a second protein and learn that this mutation also preventsmitotic cyclin from being degraded at the onset of mitosis. even when mitotic cyclin is normal the degradation of otherproteins appears to proceed normally in such cells. a mutation in what kind of protein might explain such results?

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