What does limb explain is taking place in the human brain during the instinctual process of creating music?

Limb was on a quest to understand exactly what was happening in the brain while he was using the instinctual thought process in his own brain. So after sudying several musicians, he was able to show that the area of the brain that is connected to observation and self-monitoring is the activated when musicians are using their brain to improvise. His study also showed that the area of the brain connected with self-expression became extremely active when being creative in instrument play..

Curley's wife tells Lennie that she knows that he hurt Curley's hand.