Columbus arrived in Puerto Rico during: * his first voyage to the New World in 1492
the start of the first European settlements around 1600
his second voyage to the New World in 1493
none of the above

His second voyage to the New World in 1439

Explanation:

On November 19, 1493, during his second voyage, Christopher Columbus arrived in Puerto Rico. The indigenous Taíno culture dominated the island. The Taíno called the island Borikén (Spanish Boriquen), “the land of the brave lord.” Columbus named the island San Juan Bautista in honor of Saint John the Baptist.

There are so many examples for that in different areas, like biology experiment carried out in our lab recently.

Here's one link : https://www.creative-biogene.com/Services/Gene-Service/Gene-Synthesis-and-cloning-service.html