How do zymogens involved in blood clotting?

acts by sequential proteolytic activation, via plasma proteases, resulting in the formation of thrombin.

Explanation:

Hemostasis is a physiological process involved with blood flow and bleeding control in the face of vascular injury, initiating the tissue repair process. The coagulation system is characterized by the action of plasma proteases (coagulation factors) in the form of zymogens (pro-enzymes), by which, when activated, give rise to the active proteases (enzymes) that initiate a cascade reaction, leading to the conversion of plasma fibrinogen in fibrin polymers, forming the clot. The fibrin network stabilizes the platelet lid, accumulating red blood cells and leukocytes, giving rise to the thrombus.

Nonsense mutations produce truncated and frequently nonfunctional proteins

Explanation: