How did american indians react to american settlers in the late 1700s and early 1800s? a.most american indians lived west of the appalachians, so settlement had little effect on them. b.settlement affected american indians very little, but they resented the arrival of explorers. c.the two groups were trading partners, so both sides lived in peaceful coexistence.d. american settlers and american indians often clashed as settlement spread across t

D. Is the Indians did not like the idea of others taking their land. Some attacked the settlers. Some tried to help, in hoping for peace. Some like Pocahontas saved ones life many times. Like John smith's life. She thought he mattered. Rate me, and if this helped, thank me. If this really helped do all including crowning me brainiest answer. Thanks means a lot. Also comment helps me to improve.

D. American settlers and American Indians often clashed as settlement spread across the West during that era.

The answer is a to this one