Suppose you are a settler in the brittish colonies. you want to settle on land where the ohio river meets the mississippi river. traveling over land, what might be a good route?

The major physical feature that you would have to cross in order to reach this destination would be the Appalachian Mountains, since these were so large that they discouraged travel to this region for quite some time. 

The immigrants who came to United States during the 19th and early 20th centuries largely came either for economic opportunities or to escape a negative situation in their home countries. For instance, in the 1840s, Irish immigration peaked during the Irish famine, while Asian immigrants came mostly for jobs on the railroads in the West. Refugees from war and conflict were another regular source of immigrants to the United States.